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Colic is a condition manifested as inconsolable crying episodes in infants and associated with adverse effects such as maternal depression, child abuse and deterioration in the child’s quality of life. The exact etiology of IC remains elusive; however, a number of non-gastrointestinal and gastrointestinal factors have been implicated. Transient lactose intolerance has been identified as a possible causative factor in IC. However, restriction of lactose from the infants diet is not considered to be feasible as it can limit calcium absorption. Lactase supplementation has been considered beneficial for the management of symptoms associated with lactose intolerance.

Moreover, lactase may also be effective for the management of IC sa it has been shown to reduce crying time and symptoms of lactose intolerance in colicky infants.